Lapeer · Rochester Hills · Telehealth

Cancer Screening
& Prevention
The Gynecologic Cancers That Are Most Preventable — When Screening Finds Them Early

Gynecologic cancer screening is one of the highest-value clinical services in women’s health — not because it detects cancer that has already developed, but because it finds precancerous and early changes before they become cancer, and because it identifies women at elevated risk who benefit from closer surveillance. The difference between cervical cancer found at Stage I and Stage III is almost entirely a function of whether screening was current. The same is true for many gynecologic cancers.

Dr. Ramona D. Andrei, MD, PhD, FACOG provides comprehensive gynecologic cancer screening, risk assessment, and prevention-focused care at both our Lapeer and Rochester Hills offices.

Board-certified gynecology & minimally invasive surgery  ·  Most major insurances accepted
Serving Lapeer County & Oakland County

Gynecologic Cancer Screening — Prevention Is the Point

Cancer screening does not prevent cancer by finding it — it prevents cancer by finding what comes before it. Cervical cancer screening detects HPV infection and precancerous cervical dysplasia years before invasive cancer develops. Endometrial cancer is identified early when women report postmenopausal bleeding rather than dismissing it. Ovarian cancer — the most difficult to detect — is caught at a more treatable stage when its warning signs are recognized and acted on rather than attributed to other causes. And women with hereditary risk factors identified through family history and genetic testing receive targeted surveillance that dramatically improves their outcomes compared with women whose elevated risk was never recognized.

The gynecologist is the primary point of contact for most women’s cancer screening needs. The well-woman visit is not simply an annual formality — it is the clinical encounter where screening status is reviewed, family history is updated, new symptoms are evaluated, and screening recommendations are tailored to each woman’s individual risk profile. At Lapeer Women’s Health, cancer prevention is embedded in every well-woman visit and addressed specifically as a clinical priority at every age.

Gynecologic Cancer Screening — What This Cluster Covers

Each page in this cluster addresses a specific domain of gynecologic cancer screening and prevention in depth. Together they cover the full scope of cancer risk that a gynecologic practice is positioned to identify, screen for, and act on.

Cervical Cancer Screening

Cervical cancer is among the most preventable cancers in medicine — because its causative agent (HPV) is known, its precancerous phase is long and detectable, and the screening system that identifies and treats precancerous changes before invasion occurs is highly effective when used consistently. Current Pap and HPV co-testing guidelines, vaccination recommendations, and the complete cervical cancer prevention pathway are covered in depth. Learn more →

Postmenopausal Bleeding & Cancer Risk

Postmenopausal bleeding — any vaginal bleeding that occurs after 12 consecutive months without a period — is never normal and always requires evaluation. Endometrial cancer presents as postmenopausal bleeding in the majority of cases, and when identified at this stage, before symptoms are dismissed or attributed to other causes, it is highly curable. The evaluation that begins with postmenopausal bleeding and ends with a definitive diagnosis is straightforward — and the cost of delaying it is not. Learn more →

Breast Cancer Screening Referrals

The gynecologist performs clinical breast examination and coordinates referrals for mammography and supplemental breast imaging — often serving as the provider who ensures breast cancer screening is current, who identifies women who may benefit from supplemental MRI screening based on density or risk, and who acts on breast examination findings that warrant further evaluation. Breast cancer screening recommendations by age and risk category are reviewed at the well-woman visit at Lapeer Women’s Health. Learn more →

Family History & Gynecologic Cancer Risk

Family history of breast, ovarian, endometrial, or colorectal cancer is one of the most powerful predictors of individual cancer risk — and one of the most underutilized pieces of clinical information in gynecologic care. A detailed, three-generation family history reviewed at the well-woman visit identifies women who may benefit from genetic counseling, enhanced screening, or prophylactic interventions that dramatically reduce cancer risk. Many women with significant hereditary cancer risk have never had it recognized because no one took a thorough family history. Learn more →

Genetic Testing for Cancer Risk

BRCA1 and BRCA2 mutations, Lynch syndrome, and other hereditary cancer syndromes confer dramatically elevated lifetime risks of gynecologic and other cancers that standard population-based screening does not adequately address. Genetic testing — when appropriately indicated by personal or family history — identifies women who need individualized high-risk management including enhanced surveillance, chemoprevention, and potentially risk-reducing surgery. The clinical pathway from family history concern to genetic counseling referral to result-based management is coordinated at Lapeer Women’s Health. Learn more →

Ovarian Cancer Warning Signs

Ovarian cancer is the most lethal gynecologic cancer because it is diagnosed at an advanced stage in the majority of cases — not because it is inherently untreatable when found early. The warning signs of ovarian cancer are real, recognizable, and frequently attributed to more common benign conditions for months before the diagnosis is made. Understanding which symptoms warrant prompt gynecologic evaluation — and advocating for that evaluation — is one of the most important things a woman can do for her own cancer outcomes. Learn more →

Symptoms That Warrant Prompt Gynecologic Evaluation

The following symptoms should not be dismissed or watched for more than a few weeks before seeking evaluation:

  • Any vaginal bleeding after menopause — even a small amount, even once — requires evaluation
  • New, persistent pelvic or abdominal bloating, pressure, or fullness that is different from your normal pattern
  • New difficulty eating or feeling full quickly that has persisted for more than a few weeks
  • New urinary urgency or frequency without an identified infection in a postmenopausal woman
  • Unexplained pelvic or abdominal pain that is new, persistent, or worsening
Lapeer: (810) 969-4670  ·  Rochester Hills: (248) 923-3522
Gynecologic Cancer Risk — What Increases It and What Reduces It

Understanding cancer risk is not about predicting inevitability — it is about identifying which women need closer surveillance, which need genetic evaluation, and which modifiable factors can meaningfully reduce risk.

Cervical Cancer Risk

Virtually all cervical cancer is caused by persistent infection with high-risk HPV strains. Risk factors that increase the probability of HPV persistence and dysplasia progression include: smoking (which significantly impairs local cervical immune defense), immunosuppression from any cause, early sexual debut, multiple sexual partners, and failure to maintain current Pap and HPV screening. HPV vaccination dramatically reduces risk for the strains covered by the vaccine. Consistent cervical cancer screening is the most powerful preventive intervention available for women who are sexually active regardless of vaccination status.

Endometrial Cancer Risk

Endometrial cancer is the most common gynecologic malignancy in the United States. The primary driver is sustained exposure of the uterine lining to estrogen without adequate progesterone opposition. Risk factors include obesity (adipose tissue produces estrogen independently of the ovaries), diabetes, unopposed estrogen therapy, late menopause, nulliparity, and Lynch syndrome. Combined oral contraceptives and progestin-containing IUDs significantly reduce endometrial cancer risk by providing progestin exposure to the uterine lining — a non-contraceptive benefit that is relevant to the contraceptive counseling conversation at Lapeer Women’s Health. PCOS is an independent risk factor through the mechanism of chronic anovulation and unopposed estrogen.

Ovarian Cancer Risk

Ovarian cancer risk is influenced primarily by genetics and ovulatory history. BRCA1 and BRCA2 mutations confer lifetime ovarian cancer risks of 40 to 46 percent and 11 to 27 percent respectively — compared to a 1.4 percent lifetime risk in the general population. Each ovulatory cycle produces minor trauma to the ovarian surface; factors that reduce lifetime ovulatory cycles (oral contraceptive use, pregnancy, breastfeeding) reduce ovarian cancer risk. Women with a significant family history of ovarian, breast, or colorectal cancer require specific risk assessment and potentially genetic counseling to determine whether their risk warrants enhanced surveillance or prophylactic intervention.

Hereditary Cancer Syndromes

A minority of gynecologic cancers occur in the context of hereditary cancer syndromes where the risk is dramatically elevated above the population baseline. BRCA1/2 mutations are associated with significantly elevated breast and ovarian cancer risk. Lynch syndrome (hereditary nonpolyposis colorectal cancer) is associated with elevated endometrial and ovarian cancer risk alongside colorectal cancer risk. Identifying these syndromes requires taking a detailed three-generation family history, recognizing the patterns that suggest hereditary risk, and referring for genetic counseling when indicated. Women whose hereditary risk is identified can access interventions — enhanced surveillance, chemoprevention, prophylactic surgery — that reduce their cancer risk substantially.

Cancer Screening at Lapeer Women’s Health

Cancer screening and prevention at Lapeer Women’s Health is integrated into every well-woman visit and addressed with specific clinical attention by Dr. Ramona D. Andrei, MD, PhD, FACOG.

Screening Status Review at Every Well-Woman Visit

Every well-woman visit at Lapeer Women’s Health includes a systematic review of current screening status: cervical cancer screening interval and last result, breast cancer screening status and last mammogram, colorectal cancer screening status, and any new symptoms that have developed since the last visit. Overdue screening is identified and addressed proactively rather than waiting for the patient to raise it.

Family History Assessment and Risk Stratification

A detailed family history of cancer — type, age at diagnosis, maternal and paternal lineage — is reviewed and updated at the annual well-woman visit. Women whose family history suggests hereditary cancer risk receive specific discussion of what that risk means, what enhanced screening or genetic evaluation is recommended, and how to access genetic counseling through our affiliated network.

Symptom Evaluation Without Delay

New symptoms that may reflect gynecologic cancer — postmenopausal bleeding, persistent pelvic bloating, pressure or pain, new urinary or bowel changes — are evaluated promptly at Lapeer Women’s Health rather than observed and reassured. The evaluation that identifies early cancer is the same evaluation that rules it out — and its value is the same in either case.

The Best Time to Screen Is Before There Are Symptoms

The cancers with the best outcomes are the ones found before they produce symptoms — because symptoms often mean the cancer has advanced beyond the stage where treatment is simplest and most effective. Cervical cancer found at Stage I has a five-year survival rate above 90 percent. Endometrial cancer found at Stage I has a five-year survival rate above 95 percent. Ovarian cancer found at Stage I has a five-year survival rate above 90 percent. The same cancers found at Stage III or IV have survival rates that are a fraction of these numbers.

The annual well-woman visit at Lapeer Women’s Health — at either our Lapeer or Rochester Hills offices — is the mechanism by which screening is kept current, risk is assessed, and early symptoms are evaluated before they become late findings. No referral required.

Frequently Asked Questions About
Gynecologic Cancer Screening
No reliable population-based screening test for ovarian cancer currently exists. CA-125 blood testing and transvaginal ultrasound have been studied extensively as screening tools but have not been shown to reduce ovarian cancer mortality in the general population — primarily because ovarian cancer is biologically heterogeneous and most early-stage disease does not produce reliably elevated CA-125 levels. For women with BRCA1/2 mutations or other hereditary risk factors, transvaginal ultrasound and CA-125 testing are used as part of high-risk surveillance protocols, but their sensitivity even in this setting is limited. The most effective ovarian cancer risk-reduction intervention for high-risk women is risk-reducing salpingo-oophorectomy at an age determined by their specific mutation and risk profile. Recognizing ovarian cancer symptoms and seeking prompt evaluation remains the most practical tool for the general population.
Yes. The majority of gynecologic cancers occur in women without a significant family history. Family history is one risk factor among many, and its absence does not substantially reduce the importance of population-based screening at recommended intervals. Cervical cancer can occur in any woman who has been sexually active regardless of family history. Endometrial cancer is the most common gynecologic cancer and most cases occur sporadically without hereditary predisposition. Standard cervical cancer screening, prompt evaluation of postmenopausal bleeding, and clinical breast examination remain important regardless of family history. Family history shapes the intensity and modality of surveillance — it does not determine whether surveillance is needed at all.
No. The HPV vaccine protects against the nine HPV strains covered in Gardasil 9, which together account for the majority of cervical cancers — but not all of them. Women who have been vaccinated still require cervical cancer screening at recommended intervals because not all oncogenic HPV strains are covered and because vaccination does not reverse prior HPV exposures. The interval and method of cervical cancer screening are the same for vaccinated and unvaccinated women currently. As fully vaccinated generations age through the screening population, guidelines may be revised — but at this time, vaccination does not replace screening.
Lynch syndrome is a hereditary cancer syndrome caused by mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2) that significantly elevates lifetime risk of colorectal, endometrial, ovarian, and several other cancers. Women with Lynch syndrome have a lifetime endometrial cancer risk of 40 to 60 percent and an ovarian cancer risk of 10 to 12 percent. Testing for Lynch syndrome is considered when a woman has a personal or family history of colorectal cancer at a young age, multiple Lynch-associated cancers in close relatives, or endometrial cancer before age 50. If your family history suggests Lynch syndrome, Dr. Andrei will discuss genetic counseling referral at your visit.
Current guidelines recommend discontinuing cervical cancer screening after age 65 in women who have had adequate prior negative screening — defined as three consecutive negative Pap tests or two consecutive negative co-tests within the past 10 years, with the most recent test within the past 5 years. Women who have had a hysterectomy with removal of the cervix and no prior history of high-grade dysplasia or cervical cancer may also discontinue Pap testing. Women with a history of CIN 2, CIN 3, or cervical cancer should continue surveillance for at least 20 years after treatment regardless of age. The specific recommendation for discontinuing screening is individualized based on your screening history at Lapeer Women’s Health.
Yes. Gynecologic cancer screening, risk assessment, and referral coordination are available at both the Lapeer office (1245 N Main St, Lapeer, MI — (810) 969-4670) and the Rochester Hills office (2710 S Rochester Rd, Suite 2, Rochester Hills, MI — (248) 923-3522). No referral is required to schedule.
Board-certified gynecology & minimally invasive surgery  ·  Most major insurances accepted  ·  Convenient locations in Lapeer & Rochester Hills
Cancer Found Early Is Cancer Treated Successfully. Keep Your Screening Current.

Our team at Lapeer Women’s Health provides comprehensive gynecologic cancer screening and risk assessment at both our Lapeer and Rochester Hills offices. No referral required.

Schedule a Gynecologic Visit

The information on this page is intended for educational purposes only and does not constitute medical advice. Individual risk factors, screening intervals, and management plans vary significantly based on personal and family history. Content reviewed by Dr. Ramona D. Andrei, MD PhD FACOG.

Gynecologic care for women of every age

Lapeer Women’s Health — Rochester Hills
2710 S Rochester Rd, Suite 2
Rochester Hills, MI 48307

Serving patients in Lapeer, Rochester Hills, and surrounding communities throughout Southeast Michigan.